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A large segment of India’s rural population depends on agriculture for its livelihood, yet difficulties with manual processes and disease management persist. To address these problems, this study presents an automated framework for detecting leaf damage and identifying plant diseases using advanced deep learning methods. The introduced technique unfolds in six steps: first, YOLOv8 is harnessed to pinpoint regions of interest from drone-acquired images; second, DeepLabV3+ is applied for background stripping to aid disease categorization; third, a CNN model is deployed for reliable disease sorting, registering strong training and validation accuracy figures (96.97% and 92.89%, respectively); fourth, UNet-based semantic segmentation is utilized for meticulous pixel-scale damage identification, with an assessment accuracy of 99%; fifth, disease severity is gauged; and sixth, customized remedial measures are put forward according to the disease category and the extent of damage. Experimental trials using the Plant Village dataset confirm the technique’s ability to detect various defects across crops, including apple, tomato, and corn. This mechanized strategy carries significant potential to boost agricultural output and strengthen disease management both within India and globally.